Film Coated Oral Medications Premarin Conjugated Estrogens Tablets
Product : Conjugated Estrogens Film Coated Tablets
Specification : Film coated Tablets, 0.3mg, 0.45mg, 0.625mg,0.9mg,
Standard : In - house
Packing : 28’s/blister, box
Conjugated estrogens tablets, USP, for oral administration contains
a mixture of conjugated estrogens obtained exclusively from natural
sources, occurring as the sodium salts of water-soluble estrogen
sulfates blended to represent the average composition of material
derived from pregnant mares' urine. It is a mixture of sodium
estrone sulfate and sodium equilin sulfate. It contains as
concomitant components, as sodium sulfate conjugates,
17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin. Tablets
for oral administration are available in 0.3 mg, 0.45 mg, 0.625 mg,
0.9 mg, and 1.25 mg strengths of conjugated estrogens.
Indications and Usage :
Conjugated Estrogens Film coated tablets therapy is indicated in
1. Treatment of moderate to severe vasomotor symptoms due to
2. Treatment of moderate to severe symptoms of vulvar and vaginal
atrophy due to menopause. When prescribing solely for the treatment
of symptoms of vulvar and vaginal atrophy, topical vaginal products
should be considered.
3. Treatment of hypoestrogenism due to hypogonadism, castration or
primary ovarian failure.
4. Treatment of breast cancer (for palliation only) in
appropriately selected women and men with metastatic disease.
5. Treatment of advanced androgen-dependent carcinoma of the
prostate (for palliation only).
6. Prevention of postmenopausal osteoporosis. When prescribing
solely for the prevention of postmenopausal osteoporosis, therapy
should only be considered for women at significant risk of
osteoporosis and for whom non-estrogen medications are not
considered to be appropriate.
The mainstays for decreasing the risk of postmenopausal
osteoporosis are weight-bearing exercise, adequate calcium and
vitamin D intake, and when indicated, pharmacologic therapy.
Postmenopausal women require an average of 1500 mg/day of elemental
calcium. Therefore, when not contraindicated, calcium
supplementation may be helpful for women with suboptimal dietary
intake. Vitamin D supplementation of 400-800 IU/day may also be
required to ensure adequate daily intake in postmenopausal women.